Epinephrine auto-injectors are easy to use, with a concealed needle that contains a pre-measured dose of epinephrine.

They are intramuscular devices that should be injected into the muscle on the outer side of the thigh to release the medication.

There are currently two epinephrine auto-injectors available in North America:

  • EpiPen®
  • Twinject®

Both products come in two dosages or strengths – 0.15 mg and 0.30 mg – which are prescribed based on weight.


According to product instructions, the 0.30 mg dosage of both the EpiPen® and Twinject® auto-injectors should be used for adults and children weighing 30 kg or more; and the 0.15 mg dosage should be used for children weighing between 15 kg to 30 kg. Individuals or their caregivers should consult with their physician to determine the appropriate dosage, including the switch from the lower dosage to the higher dosage.

Body Position

There are several body positions to consider when administering epinephrine:
  • If an individual is having difficulty breathing, keep them in an upright position.
  • If they are feeling faint or dizzy, they should be placed on their back with their legs raised above heart level.
  • If they are vomiting, they should be placed on their side with their head down.
  • If an individual’s condition is worsening (but they are conscious and not vomiting), they should be placed in a recumbent position (on their back) while awaiting transport to the hospital.